Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro
نویسندگان
چکیده
منابع مشابه
Novel diamidines with activity against Babesia divergens in vitro and Babesia microti in vivo.
Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The in vitro activities of novel diamidine compounds against the Babesia divergens strains 1903B and 4201 were investigated. The most potent compound, a diphenyl furan, had a 50% inhibitory concentration (IC(50)) of 1.5 ng/ml. In a murine mode...
متن کاملInhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice.
INTRODUCTION Different results have been achieved in the evaluation of antiparasitic drug activity in Mongolian jirds, hamsters, and BALB/c mice infected with Babesia microti. The aims of the present study were to find a preferable method for drug screening and to re-evaluate the activity of several drugs against B. microti. METHODOLOGY The activity of 19 drugs on B. microti-infected BALB/c m...
متن کاملGrowth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures.
Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in...
متن کاملBabesia microti, Upstate New York
Five cases of human babesiosis were reported in the Lower Hudson Valley Region of New York State in 2001. An investigation to determine if Babesia microti was present in local Ixodes scapularis ticks yielded 5 positive pools in 123 pools tested, the first detection of B. microti from field-collected I. scapularis in upstate New York.
متن کاملTransfusion-Transmitted Babesia microti Risks Transfusion-Transmitted Babesia microti Identified Through Hemovigilance
Background: Babesia microti, a tick-borne parasite endemic to the northeast and upper Midwest, is the primary cause of human babesiosis in the United States. Although these infections are usually subclinical or self-limited in immunocompetent people, severe disease can be present in susceptible populations (including the elderly or immunocompromised). Here, infections result in hemolytic anemia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.00247